TRANSPLANTATION CCR1/CCL5 (RANTES) receptor-ligand interactions modulate allogeneic T-cell responses and graft-versus-host disease following stem-cell transplantation
نویسندگان
چکیده
1Department of Pediatrics, Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor; 2Department of Hematology and Oncology, University of Regensburg, Regensburg, Germany; 3Cancer Center Bioinformatics Core, University of Michigan, Ann Arbor; 4Department of Pathology, University of Florida School of Medicine, Gainesville; 5Cancer Center Flow Cytometry Core, University of Michigan, Ann Arbor; and 6Department of Pathology, University of Michigan, Ann Arbor
منابع مشابه
CCR1/CCL5 (RANTES) receptor-ligand interactions modulate allogeneic T-cell responses and graft-versus-host disease following stem-cell transplantation.
Acute graft-versus-host disease (GVHD) and leukemic relapse are serious complications of allogeneic stem-cell transplantation (SCT). Recruitment of activated T cells to host target tissues or sites of leukemic infiltration (graft-versus-leukemia [GVL]) is likely mediated by chemokine receptor-ligand interactions. We examined the contribution of donor cell CCR1 expression to the development of G...
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Idiopathic pneumonia syndrome (IPS) is a major cause of mortality following allogeneic stem cell transplantation (allo-SCT). Clinical and experimental data support a role for conditioning-induced inflammation and alloreactive T-cell responses in IPS pathophysiology, but the mechanisms by which donor leukocytes are ultimately recruited to the lung are not fully understood. RANTES is a chemokine ...
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Background : Graft versus host disease (GVHD) is among major complications of allogeneic hematopoietic stem cells transplantation, and also is an important factor affecting the outcome of transplantation. An increased incidence of GVHD has been suggested following allogeneic peripheral blood stem cells (PBSC) transplantation, however, how this affects survival is not yet well clear. In this stu...
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